Altered Glycemic Status Modulates Gastrointestinal Motility in Male Wistar Rats

Glucose derangement is a common endocrine disorder affecting over 463 million worldwide. Its attending complications on the gastrointestinal motility in altered glycemic states were investigated. Forty-five male Wistar rats grouped into 3 (n=15/group): Group 1- Control, 2- Diabetes, 3- Postprandial hyperglycemia. The 15 per group sub-grouped of 5 each. Each sub-group determined gastric emptying, intestinal propulsion, and colonic motility. Diabetes was induced with single intraperitoneal 150 mg/kg alloxan postprandial received an oral D - glucose load 2 g/kg. Before commencement each experimental procedure, all groups fasted for 18 hours blood concentration assessed by oxidase method after 45 min onset experiment. mean ± SEM data subjected to one-way ANOVA analysis values p<0.05 considered significant. There significant decrease fasting level (mmol/L) control (3.64 0.10) compared diabetic (31.94 2.38). percentage emptying decreased significantly diabetics. propulsion (42.14 3.14) increased (7.43 1.05) when (72.91 5.47). time diabetic. promotes delay different examined while supported propulsion. Further work should focus identifying mechanism involved.